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pentobarbital will decrease the extent or result of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals mustn't decide on estradiol valerate/dienogest as their contraceptive although making use of sturdy CYP3A4 inducers due to probable lower in contraceptive efficacy.Contraindicated (one)pe